Publications Preceding GENICA

Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study.
Tsantoulis PK, Kotsinas A, Sfikakis PP, Evangelou K, Sideridou M, Levy B, Mo L, Kittas C, Wu XR, Papavassiliou AG, Gorgoulis VG
Oncogene 27: 3256-64, 2008

An oncogene-induced DNA damage model for cancer development.
Halazonetis TD, Gorgoulis VG, Bartek J
Science 319: 1352-1355, 2008

DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours.
Bartkova J, Horejsí Z, Sehested M, Nesland JM, Rajpert-De Meyts E, Skakkebaek NE, Stucki M, Jackson S, Lukas J, Bartek J
Oncogene 26: 7414-7422, 2007

Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B, Kotsinas A, Nahum O, Zoumpourlis V, Kouloukoussa M, Lygerou Z, Taraviras S, Kittas C, Bartkova J, Papavassiliou AG, Bartek J, Halazonetis TD, Gorgoulis VG
Cancer Res. 67: 10899-10909, 2007

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Ørntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG
Nature 444: 633-637, 2006

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.
Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA Jr, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD
Nature 434: 907-913, 2005

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.
Bartkova J, Horejsí Z, Koed K, Krämer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Ørntoft T, Lukas J, Bartek J
Nature 434: 864-870, 2005

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer..
DiTullio RA Jr, Mochan TA, Venere M, Bartkova J, Sehested M, Bartek J, Halazonetis TD.
Nat Cell Biol. 4: 998-1002, 2004

Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer. .
Halazonetis TD.
DNA Repair (Amst). 3:1057-1062, 2004

The DNA damage checkpoint and human cancer. .
Schultz LB, Chehab NH, Malikzay A, DiTullio RA Jr, Stavridi ES, Halazonetis TD.
Cold Spring Harb Symp Quant Biol. 65:489-498, 2000