Publications Funded by GENICA

Loss of p14(ARF) confers resistance to heat shock- and oxidative stress-mediated cell death by upregulating beta-catenin.
Damalas A , Velimezi G , Kalaitzakis A , Liontos M , Papavassiliou AG , Gorgoulis V , Angelidis C
Int J Cancer. 128: 1989-95, 2011

Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas.
Oster B , Thorsen K , Lamy P , Wojdacz TK , Hansen LL , Birkenkamp-Demtröder K , Sørensen KD , Laurberg S , Orntoft TF , Andersen CL
Int J Cancer. 0:0, 2011

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia.
Devgan SS, Sanal O, Doil c, Nakamura K, Pettijohn K, Nahas SA, Bartek J, Lukas C, Gatti RA
Cell Death and Differentiation. 0:0, 2011

HDACs link DNA damage response, double strand break processing and autophagy.
Robert T., Vanoli F., Chiolo I., Shubassi G., Bernstein K. A., Rothstein R., Botrugno O. A., Parazzoli D., Oldani A., Minucci S. and Foiani M
Nature. 471: 74-9, 2011

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.
Di Micco R , Sulli G , Dobreva M , Liontos M , Botrugno OA , Gargiulo G , Dal Zuffo R , Matti V , d'Ario G , Montani E , Mercurio C , Hahn WC , Gorgoulis V , Minucci S , d'Adda di Fagagna F
Nature Cell Biol. 13: 292-302, 2011

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.
Schramek D, Kotsinas A, Meixner A, Wada T, Elling U, Pospisilik JA, Neely GG, Zwick RH, Sigl V, Forni G, Serrano M, Gorgoulis VG, Penninger JM
Nat Genet. 46: 212-9, 2011

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress.
Lukas C, Savic V, Bekker-Jensen S, Doil C, Neumann B, Søvhøj Pedersen R, Grofte M, Chan KL, Hickson ID, Bartek J, Lukas J
Nature Cell Biology. 13: 243-53, 2011

High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle-assembly checkpoint.
Niittymäki I , Gylfe A , Laine L , Laakso M , Lehtonen HJ , Kondelin J , Tolvanen J , Nousiainen K , Pouwels J , Järvinen H , Nuorva K , Mecklin JP , Mäkinen M , Ristimäki A , Orntoft TF , Hautaniemi S , Karhu A , Kallio MJ , Aaltonen LA
Carcinogenesis. 32: 305-11, 2011

High [LDA1] expression of karyopherin alpha 2 (KPNA2) defines poor prognosis in non-muscle invasive bladder cancer and following radical cystectomy.
Jensen JB , Munksgaard PP , Sørensen CM , Fristrup N , Birkenkamp-Demtroder K , Ulhøi BP , Jensen KM , Orntoft TF , Dyrskjøt L
European Urology. 0: 0, 2011

Genomic instability in induced stem cells.
Pasi CE , Dereli-Öz A , Negrini S , Friedli M , Fragola G , Lombardo A , Van Houwe G , Naldini L , Casola S , Testa G , Trono D , Pelicci PG
Cell Death Differentiation. 0: 0, 2011

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).
Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J
Cell Cycle. 10: 457-68, 2011

Rseg - an R package to optimize segmentation of SNP array data.
Lamy P, Wiuf C, Orntoft TF, Andersen CL
Bioinformatics. 27: 419-20, 2011

SIRT1 contributes to telomere maintenance and augments global homologous recombination.
Palacios JA, Herranz D, De Bonis ML, Velasco S, Serrano M, Blasco MA
J Cell Biol. 191: 1299-313, 2010

Frequent genomic loss at chr16p13.2 is associated with poor prognosis in colorectal cancer.
Andersen CL, Lamy P, Thorsen K, Kjeldsen E, Wikman F, Villesen P, Oster B, Laurberg S, Orntoft TF
Int J Cancer.0: 0, 2010

Oncogene-induced senescence: the bright and dark side of the response.
Gorgoulis V. G., Halazonetis TD
Current Opinion Cell Biology. 22: 816-27, 2010

Comprehensive genome methylation analysis in bladder cancer; identification and validation of novel methylated genes and application of these as urinary tumor markers.
Thomas Reinert, Charlotte Modin, Philippe Lamy, Tomasz K Wojdacz, Lise Lotte Hansen, Carsten Wiuf, Michael Borre, Lars Dyrskjøt,Torben F. Ørntoft
Clin Cancer Res . 0: 0, 2010

Integrative functional genomics analysis of sustained polyploidy phenotypes in breast cancer cells identifies an oncogenic profile for GINS2.
Rantala JK, Edgren H, Lehtinen L, Wolf M, Kleivi K, Moen Vollan HK, Aaltola AR, Laasola P, Kilpinen S, Saviranta P, Iljin K, Kallioniemi O
Neoplasia. 12: 877-88, 2010

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.
Cescutti R., Negrini S., Kohzaki M., and Halazonetis T D
EMBO J. 29: 3723-32 2010

A lethal combination for cancer cells: Synthetic lethality screenings for drug discovery.
Ferrari E., Lucca C., Foiani M
Eur J Cancer. 46: 2889-95, 2010

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage.
Larsen DH, Poinsignon C, Gudjonsson T, Dinant C, Payne MR, Hari FJ, Danielsen JMR, Menard P, Sand, JC, Stucki M, Lukas C, Bartek J, Andersen JS, Lukas J
J. Cell Biol. 190: 731-40, 2010

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining.
Miller KM, Tjeertes JV, Coates J, Legube G, Polo SE, Britton S, Jackson SP
Nat Struct Mol Biol. 17: 1144-51, 2010

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4.
Polo SE, Kaidi A, Baskcomb L, Galanty Y, Jackson SP
EMBO J. 29: 3130-9, 2010

Why is p53-inducible gene 3 rarely affected in cancer?
Kotsinas A , Pateras IS , Galanos PS , Karamouzis MV , Sfikakis PP , Gorgoulis VG
Oncogene . 29: 5220, 2010

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas.
Bartkova J, Hamerlik P, Stockhausen MT, Ehrmann J, Hlobilkova A, Laursen H, Kalita O, Kolar Z, Poulsen HS, Broholm H, Lukas J, Bartek J
Oncogene. 29: 5095-102, 2010

A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemias.
Gruszka AM, Lavorgna S, Consalvo MI, Ottone T, Martinelli C, Cinquanta M, Ossolengo G, Pruneri G, Buccisano F, Divona M, Cedrone M, Ammatuna E, Venditti A, de Marco A, Lo-Coco F, Pelicci PG
Blood. 116: 2096-102, 2010

Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements.
Fachinetti D., Bermejo R., Cocito A., Minardi S., Katou Y., Kanoh Y., Shirahige K., Azvolinsky A., Zakian V.A., Foiani M
Mol Cell. 39:595-605, 2010

The roles of p27 (Kip 1) and DNA damage signaling in the chemotherapy induced delayed cell cycle checkpoint.
Liontos M, Velimezi G, Pateras IS, Angelopoulou R, Papavassiliou AG. Bartek J, Gorgoulis VG
J Cell Mol Med. 14: 2264-67, 2010

Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling.
Hubackova S, Novakova Z, Krejcikova K, Kosar M, Dobrovoina J, Duskova P, Hanzlikova H, Vancurova M, Barath P, Bartek J, Hofny Z
Cell Cycle. 9 :3085-99, 2010

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.
Martínez P, Thanasoula M, Carlos AR, Gómez-López G, Tejera AM, Schoeftner S, Domínguez O, Pisano DG, Tarsounas M, Blasco MA
Nat Cell Biol. 12 :768-80, 2010

p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors.
Petersen L, Hasvold G, Lukas J, Bartek J, Syljuasen RG
Cell Prolif. 43: 365-71, 2010

Heterochromatin marks HP1 gamma, HP1alpha and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours.
Bartkova J, Moudry P, Hodny Z, Lukas J, Rajpert-De Meyts E, Bartek J
Int.J Androl. 0:0, 2010

DNA damage signaling in response to double-strand breaks during mitosis.
Giunta S, Belotserkovskaya R, Jackson SP
J Cell Biol. 190: 197-207, 2010

Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73gamma in lung cancer
Logotheti S , Michalopoulos I , Sideridou M , Daskalos A , Kossida S , Spandidos DA, Field JK , Vojtesek B , Liloglou T , Gorgoulis V , Zoumpourlis V
FEBS J. 277: 3014-27, 2010

TERRA transcripts are bound by a complex array of RNA-binding proteins.
López de Silanes I, d'Alcontres MS, Blasco MA
Nat Commun. 1:1-9 10.1038/ncomms1032, 2010

Setting sights on the right target: p53 and stem cell division.
Pasi CE, Bonizzi G, Pelicci P
Cell Cycle. 9 : 0, 2010

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.
Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der GH, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S, Jonkers J
Nat Struct Mol Biol. 17:688-95, 2010

TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice.
Tejera AM, Stagno d'Alcontres M, Thanasoula M, Marion RM, Martínez P, Liao C, Flores JM, Tarsounas M, Blasco MA
Dev Cell. 18 : 775-89, 2010

HERCulean giant orchestrates ubiquitin-mediated signaling on damaged chromosomes.
Hodny Z, Mistrik M, Bartek J
Cell Cycle. 9 1227-8, 2010

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.
McNees CJ, Tejera AM, Martínez P, Murga M, Mulero F, Fernández-Capetillo O, Blasco MA
J Cell Biol. 188: 639-52, 2010

Maintaining genome stability at the replication fork.
Branzei D., Foiani M
Nat Rev Mol Cell Biol. 11: 208-19, 2010

Genomic instability - an evolving hallmark of cancer.
Negrini S , Gorgoulis V. G., Halazonetis T D
Nature Reviews Molecular Cell Biology. 11: 220-228, 2010

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content.
Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S, Bernard L, Viale G, Pelicci PG, Di Fiore PP
Cell. 140 : 62-73, 2010

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.
Bekker-Jensen S, Rendtlew DJ, Fugger K, Gromova I, Nerstedt A, Bartek J, Lukas J, Mailand N
Nat Cell Biol. 12: 80-6, sup pp 1-12, 2010

SUMO boosts the DNA damage response barrier against cancer.
Bartek J, Hodny Z
Cancer Cell. 17: 9-11, 2010

Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling.
Blazkova H, Krejcikova K, Moudry P, Frisan T, Hodny Z, Bartek J
J Cell Mol Med. 14: 357-67, 2010

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.
Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM, Jackson SP
Nature. 462: 935-9, 2009

p57KIP2: "Kip"ing the Cell under Control.
Pateras IS , Apostolopoulou K , Niforou K , Kotsinas A , Gorgoulis VG
Mol. Cancer Res. Nov 24 2009

Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations.
Schoeftner S, Blanco R, Lopez de Silanes I, Muñoz P, Gómez-López G, Flores JM, Blasco MA
Proc Natl Acad Sci U S A. 106: 19393-8, 2009

The DNA-damage response in human biology and disease.
Jackson SP, Bartek J.
Nature, 461(7267):1071-8, 2009

A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage.
loyd J, Chapman JR, Clapperton JA, Haire LF, Hartsuiker E, Li J, Carr AM, Jackson SP, Smerdon SJ
Cell. 139: 100-11, 2009

Emerging common themes in regulation of PIKKs and PI3Ks.
Lempiainen H, Halazonetis TD.
EMBO J. 28: 3067-73, 2009

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.
Cicalese A, Bonizzi G, Pasi CE, Faretta M, Ronzoni S, Giulini B, Brisken C, Minucci S, Di Fiore PP, Pelicci PG
Cell, 138(6):1083-95, 2009

Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.
Bermejo R, Capra T, Gonzalez-Huici V, Fachinetti D, Cocito A, Natoli G, Katou Y, Mori H, Kurokawa K, Shirahige K, Foiani M.
Cell, 138(5):870-84, 2009

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities.
Fugger K, Mistrik M, Danielsen JR, Dinant C, Falck J, Bartek J, Lukas J, Mailand N.
J Cell Biol. 186: 655-63, 2009

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.
Martínez P, Thanasoula M, Muñoz P, Liao C, Tejera A, McNees C, Flores JM, Fernández-Capetillo O, Tarsounas M, Blasco MA
Genes Dev. 23: 2060-75, 2009

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1.
Ahel D, Horejsi Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ
Science. 325: 1240-3, 2009

The combined status of ATM and p53 link tumor development with therapeutic response.
Jiang H, Reinhardt HC, Bartkova J, Tommiska J, Blomqvist C, Nevanlinna H, Bartek J, Yaffe MB, Hemann MT
Genes Dev. 23:1895-1909, 2009

Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis.
Mistrik M, Oplustilova L, Lukas J, Bartek J
Cell Cycle. 8: 2592-9, 2009

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity.
Marión RM, Strati K, Li H, Murga M, Blanco R, Ortega S, Fernández-Capetillo O, Serrano M, Blasco MA
Nature. 460:1149-53, 2009

Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro.
Dyrskjøt L, Ostenfeld MS, Bramsen JB, Silahtaroglu AN, Lamy P, Ramanathan R, Fristrup N, Jensen JL, Andersen CL, Zieger K, Kauppinen S, Ulhøi BP, Kjems J, Borre M, Orntoft TF.
Cancer Res. 69: 4851-60, 2009.

Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas.
Liontos M, Niforou K, Velimezi G, Vougas K, Evangelou K, Apostolopoulou K, Vrtel R, Damalas A, Kontovazenitis P, Kotsinas A, Zoumpourlis V, Tsangaris GT, Kittas C, Ginsberg D, Halazonetis TD, Bartek J, Gorgoulis VG.
Am J Path. 175: 376-91, 2009.

The checkpoint response to replication stress.
Branzei D, Foiani M.
DNA Repair. 8:1038-46, 2009.

Chronic NF-kappaB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response.
Batsi C, Markopoulou S, Vartholomatos G, Georgiou I, Kanavaros P, Gorgoulis VG, Marcu KB, Kolettas E.
Mech Ageing Dev. 130: 409-19, 2009

Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells.
Tjeertes JV, Miller KM, Jackson SP.
EMBO J. 28: 1878-89, 2009

Human CtIP mediates cell-cycle control of DNA-end resection and double-strand-break repair.
Huertas P, Jackson SP
J Biol Chem. 284: 9558-65, 2009

SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1.
Woodcock SA, Rooney C, Liontos M, Connolly Y, Zoumpourlis V, Whetton AD, Gorgoulis VG, Malliri A.
Mol Cell. 33: 639-53, 2009

The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.
Sollier J, Driscoll R, Castellucci F, Foiani M, Jackson SP, Branzei D.
Mol Biol Cell. 20: 1671-82, 2009

TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis.
Muñoz P, Blanco R, de Cárcer G, Schoeftner S, Benetti R, Flores JM, Malumbres M, Blasco MA
Mol Cell Biol 29:1608-25, 2009

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C.
Cell. 136: 435-46, 2009

Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells.
Marión RM, Strati K, Li H, Tejera A, Schoeftner S, Ortega S, Serrano M, Blasco MA
Cell Stem Cell. 4: 141-54, 2009

An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks.
Zgheib O, Pataky K, Brugger J, Halazonetis TD.
Mol Cell Biol. 29: 1050-8, 2009

Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.
Daskalos A, Nikolaidis G, Xinarianos G, Savvari P, Cassidy A, Zakopoulou R, Kotsinas A, Gorgoulis V, Field JK, Liloglou T.
Int J Cancer. 124: 81-7, 2009

Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53 activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex.
Trougakos IP, Lourda M, Antonelou MH, Kletsas D, Gorgoulis VG, Papassideri IS, Zou Y, Margaritis LH, Boothman DA, Gonos ES.
Clin Cancer Res. 15:48-59, 2009

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.
Viale A, De Franco F, Orleth A, Cambiaghi V, Giuliani V, Bossi D, Ronchini C, Ronzoni S, Muradore I, Monestiroli S, Gobbi A, Alcalay M, Minucci S, Pelicci PG.
Nature. 457(7225): 51-6, 2009

SUMOylation regulates Rad18-mediated template switch.
Branzei D, Vanoli F, Foiani M.
Nature. 456: 915-920, 2008

Is exclusive Skp2 targeting always beneficial in cancer therapy?
Koutsami M, Velimezi G, Kotsinas A, Evangelou K, Papavassiliou AG, Kittas C, Gorgoulis VG.
Blood. 112(12): 4777-9, 2008

Telomerase reverse transcriptase delays aging in cancer-resistant mice.
Tomás-Loba A, Flores I, Fernández-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borrás C, Matheu A, Klatt P, Flores JM, Viña J, Serrano M, Blasco MA
Cell. 135: 609-622, 2009

Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: Mre11 as a candidate familial cancer-predisposing gene.
Bartkova J, Tommiska J, Oplustilova L, Aaltonen K, Tamminen A, Heikkinen T, Mistrik M, Aittomäki K, Blomqvist C, Heikkilä P, Lukas J, Nevanlinna H, Bartek J.
Mol Oncol. 2: 296-316, 2008

DNA damage: a histone-code mediator leaves the stage.
Lukas J, Bartek J.
Nat Struct Mol Biol. 15: 430-2, 2008